Particle size and particle size distribution of lansoprazole raw materials were determined by light scattering method
Objective To establish a method for determination of particle size and particle size distribution of lansoprazole raw materials.Methods Light scattering method was used the particle refractive index was 1.57,the particle absorptivity was 0.1,the vibratory injection rate was 60%,the dispersion pressure was 3.0 Bar,the opacity was 0.5%～6%.Results The method has good repeatability,the RSD was 2.0%for d(0.1),2.1%for d(0.5),0.7%for D(0.9),0.7%for D(4,3).The middle precision is good.The RSD was 1.5%for d(0.1),1.8%for d(0.5),1.4%in d(0.9)and 0.9%in D(4,3).Conclusion The method is reliable and accurate,and can be used for the determination of particle size and particle size distribution of lansoprazole raw materials.
Light scatteringLansoprazoleParticle sizeParticle size distribution
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NSTL
万方数据
