Retrospective analysis of the efficacy of meropenem loading dose two-step infusion method in the treatment of severe infections
Objective Exploring whether the two-step infusion method of meropenem loading dose can achieve higher clinical and bacteriolog-ical efficacy in the treatment of severe infection patients compared to traditional intermittent intravenous drip method.Methods A retrospective study was conducted to collect cases of patients with severe infections treated with meropenem in a hospital in 2022.Comparative analysis and evaluation of the main clinical efficacy parameters(white blood cell count,neutrophil ratio,procalcitonin level),microbiological efficacy parameters(bacterial clearance rate),and incidence of adverse drug reactions between two dosing regimens.Results The differences in clinical efficiency and bacterial clearance rates between the two groups were not statistically significant(P＞0.05).The difference in the value of the decrease in neutrophil ratio between the two groups on the 7th day of treatment and on the day of medication discontinuation was statistically significant(P＜0.05).No adverse drug reactions occurred in either group.Conclusion The effectiveness and safety of the two-step infusion of meropenem load dose in the treatment of severe infections may be consistent with traditional intermittent intravenous infusion,but some indexes may have better clinical improvement than traditional intermittent intravenous drip method.
MeropenemLoading dose two-step infusion methodSevere infectionRetrospective study
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