A study of prevention of the risk of pre-eclampsia by the low-dose aspirin in different gestational weeks
Objective To analyze the effect of the first use of low-dose aspirin in different gestational weeks on the important biochemical and physiological indicators related to the risk of developing pre-eclampsia and the correlation of prevention of pre-eclampsia.Methods 51 pregnant women admitted to a hospital in Shenzhen from 2020 to 2021 were selected for the study,and the changes in important indicators related to pre-eclampsia after the first use of low-dose aspirin in different gestational weeks were analyzed comparatively,including changes in blood pressure,prothrombin time(PT),thrombin time(TT),activated partial thromboplastin time(APTT),fibrinogen(FIB),D-dimer(D-D),antithrombin Ⅲ(ATⅢ),total protein(TP),albumin(ALB)and urine protein.Results The conversion rate of urine protein test results from positive to negative was 68.18％after a low dose of single aspirin intervention,and the efficiency of aspirin in preventing the onset of pre-eclampsia was 94.12％.Statistically significant differences were found in the following indicators after intervention with aspirin:①PT:when intervening at less than 16 weeks of gestation,the pre-and post-intervention values were(12.08±0.85)s and(11.34±0.89)s,respectively;② ALB:when intervening at 16 weeks and after 16 weeks of gestation,the pre-and post-intervention values were(40.05±3.44)g/L and(37.20±2.96)g/L,respectively.Conclusion The first use of low-dose aspirin was effective in preventing the development of pre-eclampsia in different gestational weeks.Affecting some preeclampsia-related biochemical and physiological indicators in pregnant women at different gestational weeks,including a slight decrease in prothrombin time in pregnant women at 16 weeks and after 16 weeks of gestation,and a decrease in albumin values in pregnant women before 16 weeks of gestation.
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