摘要
目的 分析在不同孕周中首次使用小剂量阿司匹林对子痫前期相关重要生化生理指标的影响与预防子痫前期发生的相关性.方法 选取深圳市某医院 2020～2021 年 51 例首次服用阿司匹林的孕妇为研究对象,对比分析不同孕周首次服用阿司匹林后子痫前期相关重要指标的变化,包括血压、凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、D-二聚体(D-D)、抗凝血酶Ⅲ(ATⅢ)、总蛋白(TP)、白蛋白(ALB)和尿蛋白等.结果 服用小剂量阿司匹林后尿蛋白检测结果转阴率为 68.18%,阿司匹林预防子痫前期发生的有效率为 94.12%.首次服用阿司匹林后有统计学差异的指标有:①PT:孕周≥16 时干预,其干预前后值分别为(12.08±0.85)s,(11.34±0.89)s;②ALB:孕周＜16 时干预,其干预前后值分别为(40.05±3.44)g/L,(37.20±2.96)g/L.结论 首次低剂量阿司匹林在不同孕周中均可有效预防子痫前期的发生,影响了不同孕周孕妇的部分子痫前期相关生化生理指标,其中,妊娠 16 周及以上的孕妇凝血酶原时间略降低,妊娠 16 周前孕妇白蛋白值下降.
Abstract
Objective To analyze the effect of the first use of low-dose aspirin in different gestational weeks on the important biochemical and physiological indicators related to the risk of developing pre-eclampsia and the correlation of prevention of pre-eclampsia.Methods 51 pregnant women admitted to a hospital in Shenzhen from 2020 to 2021 were selected for the study,and the changes in important indicators related to pre-eclampsia after the first use of low-dose aspirin in different gestational weeks were analyzed comparatively,including changes in blood pressure,prothrombin time(PT),thrombin time(TT),activated partial thromboplastin time(APTT),fibrinogen(FIB),D-dimer(D-D),antithrombin Ⅲ(ATⅢ),total protein(TP),albumin(ALB)and urine protein.Results The conversion rate of urine protein test results from positive to negative was 68.18％after a low dose of single aspirin intervention,and the efficiency of aspirin in preventing the onset of pre-eclampsia was 94.12％.Statistically significant differences were found in the following indicators after intervention with aspirin:①PT:when intervening at less than 16 weeks of gestation,the pre-and post-intervention values were(12.08±0.85)s and(11.34±0.89)s,respectively;② ALB:when intervening at 16 weeks and after 16 weeks of gestation,the pre-and post-intervention values were(40.05±3.44)g/L and(37.20±2.96)g/L,respectively.Conclusion The first use of low-dose aspirin was effective in preventing the development of pre-eclampsia in different gestational weeks.Affecting some preeclampsia-related biochemical and physiological indicators in pregnant women at different gestational weeks,including a slight decrease in prothrombin time in pregnant women at 16 weeks and after 16 weeks of gestation,and a decrease in albumin values in pregnant women before 16 weeks of gestation.
基金项目
2023年广东省总药师制度建设研究基金(2023ZYS10)
NETL
NSTL
万方数据