Primary study of recurrent oral ulcer microecological changes of oral flora and its clinical significance
Objective To explore the recurrent oral ulcer(ROU)and oral flora changes,to provides references for clinical prevention and treatment of ROU.Methods A total of 130 ROU patients treated in a hospital from June 2020 to May 2021 were collected,divided into ulcer group(65 cases)and healing group(65 cases)according to the stage of disease development,and 65 healthy patients in the same period were included as the control group.The differences of three groups in G+coccobacteria(G+c),G-coccobacteria(G-c),G+bacillus(G+b),G-bacillus(G-b)and coccus,straight rods,clostridia,fusiforms,curved rods,spirochetes percentages were detected and compared.Results There was a statistically significant difference in the percentages of G-c,coccus,straight rods and clostridia among the three groups(P＜0.05);The results of pairwise comparison between groups showed that the percentage of G-c in the ulcer group and the healing group was significantly lower than that in the control group(P＜0.05),and the percentage of G-c in the ulcer group was significantly lower than that in the healing group(P＜0.05);The percentage of cocus in the ulcer group was significantly lower than that in the control and healing groups(P＜0.05),the percentage of straight rods in the ulcer group was significantly higher than that in the control group(P＜0.05),and the percentage of clostridia in the ulcer group was significantly higher than that in the control and healing groups(P＜0.05).Conclusion Microbial flora changes may be related to the onset and prognosis of ROU,and clinical attention should be paid to the role of oral microecological balance in the treatment of ROU.
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