The expression of miR-21,NT-proBNP,and CTGF in patients with atrial fibrillation and their predictive value in prognosis
Objective Analyze the expression of miR-21,NT-proBNP,and CTGF in patients with atrial fibrillation and their predictive value for prognosis.Methods 100 AF patients who were treated from January 2020 to January 2022 were included as the study subjects,serving as the atrial fibrillation group,and 50 healthy individuals were selected as the control group.Compare the levels of miR-21,NT-proBNP,and CTGF between two groups of study subjects,and compare the expression of miR-21,NT-proBNP,and CTGF in patients with and without recurrent atrial fibrillation;Draw ROC curves to evaluate the predictive value of combined detection of the three for recurrence in AF patients.Results Comparison of baseline data between two groups of study subjects showed statistically significant differences in high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,Cr,hs-CRP,and D-dimer(P＜0.05).The levels of miR-21,NT-proBNP,and CTGF in the atrial fibrillation group were significantly higher than those in the control group,with statistical significance(P＜0.05).The levels of miR-21,NT-proBNP,and CTGF were significantly increased in patients with persistent atrial fibrillation,with statistical significance(P＜0.05).The levels of miR-21,NT-proBNP,and CTGF in patients with recurrence within one year were significantly increased,and the difference was statistically significant(P＜0.05).The ROC curve shows that the sensitivity(94.2%),specificity(91.8%),and AUC(93.4%)of the three combined tests in predicting 1-year recurrence in AF patients are higher than those of single indicator tests.Conclusion The expression of miR-21,NT-proBNP,and CTGF significantly increased in patients with AF,which was positively correlated with the duration of AF;The expression levels of miR-21,NT-proBNP,and CTGF were significantly increased in patients with AF recurrence,and these three factors have predictive value for postoperative recurrence in AF patients.
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