To explore the mechanism of Shengmaiyin in treating chemotherapy-induced peripheral neuropathy based on network pharmacology and molecular docking technology
Objective To explore the mechanism of Shengmaiyin in treating chemotherapy-induced peripheral neuropathy based on network pharmacology and molecular docking technology.Methods Use the Traditional Chinese Medicine System Pharmacology Database and Analysis Platform(TCMSP)to search for the chemical components of Ginseng and Schisandra in Shengmaiyin,use the BATMAN-TCM database to search for the chemical components of Ophiopogon japonicus,and use the PharmMapper platform to predict targets;Retrieve target genes related to chemotherapy-induced peripheral neuropathy through the GeneCards database;Use Venny diagrams to obtain the intersection targets of Shengmaiyin and diseases,and constructing protein interaction networks through the String online platform;Use Cytoscape software to constructing a"drug ingredient target"network;Use Rlanguage software(version 3.6.1)to perform GO functional enrichment analysis and KEGG pathway enrichment analysis;Screen core targets and their corresponding active ingredients for molecular docking validation.Results There are 49 components of Shengmaiyin in the treatment of chemotherapy-induced peripheral neuropathy,with 109 predicted targets.There are 2 132 target genes for peripheral neurotoxicity after chemotherapy.The GO analysis process involves 604 biological processes,34 cellular components,and 51 molecular functions.KEGG analysis enriched a total of 96 pathways,mainly involving lipid and atherosclerotic pathways,MAPK signaling pathways,IL-17 signaling pathways,FoxO signaling pathways,AGE-RAGE signaling pathways in diabetes complications,TNF signaling pathways,etc.Molecular docking show that the target proteins have good binding activity with its corresponding chemical components.Conclusion Shengmaiyin may act on ALB,EGFR,HSP90AA1,CASP3,SRC,ESR1,MAPK1,MAPK14,etc targets to treat chemotherapy-induced peripheral neuropathy through lipid and atherosclerosis pathways,MAPK signaling pathway,IL-17 signaling pathway,FoxO signaling pathway,AGE-RAGE signaling pathway in diabetes complications,TNF signaling pathway,etc.
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