Clinical efficacy analysis of fexofenadine hydrochloride tablets decreasing therapy in the treatment of chronic spontaneous urticaria
Objective To evaluate the clinical efficacy of fexofenadine hydrochloride tablets decreasing therapy in the treatment of chronic spontaneous urticaria.Methods 110 patients with chronic spontaneous urticaria admitted from March 2022 to September 2023 were randomly divided into the control group(n=55)and the observation group(n=55)according to the random number table method.Both groups were treated with fexofenadine hydrochloride tablets.The control group received the same dose of medication(120 mg)every day,while the observation group received dose decreasing treatment.After one month of treatment,the drug dose gradually decreased,and after two months of medication,it was controlled within the minimum dosage.Compare the medication effects of two groups of patients.Results The results of Urticaria activity score and dermatology quality of life score showed a statistically significant difference between disease status,quality of life after 1,2 and 3 months of treatment and before treatment(P＜0.05).There was no statistically significant difference in the degree of disease improvement and quality of life between the two groups of patients each month(P＞0.05);The results of antihistamine medication dosage showed that the observation group patients had significantly lower medication dosage than the control group in the second and third months of treatment(P＜0.05),and the medication dosage per month was significantly lower than the previous month(P＜0.05).The occurrence of adverse drug reactions between the two groups was similar and showed no significant difference(P＞0.05).Conclusion The clinical efficacy of fexofenadine hydrochloride tablets decreasing therapy for chronic spontaneous urticaria is similar to that of conventional dose therapy,with good therapeutic effect and safety.
万方数据
维普
