Analysis of the effects of dioxamine and ericoxib on inflammatory factors and bone metabolism in patients with osteoporotic limb fractures
Objective To analyze and investigate the effects of dioxamine combined with ericoxib on inflammatory factors and bone metabolism in osteoporotic limb fractures.Methods The study included a total of 100 patients with osteoporotic limb fractures who were admitted to hospital between June 2021 and July 2023.These patients were randomly assigned into two groups:an observation group and a control group,each consisting of 50 cases.Both groups underwent surgical treatment for limb fracture.The control group was treated with oral ericoxib tablets after surgery,and the observation group was treated with oral diosamine combined with ericoxib,both groups underwent continuous treatment for 2 weeks.The efficacy,incidence of adverse reactions,inflammatory factors and bone metabolism were compared between two groups.Results After treatment,total effective rate of the observation group was significantly higher than that of the control group(P＜0.05),and there was no significant difference in adverse reactions between the two groups(P＞0.05).The levels of interleukin2(IL-2),interleukin10(IL-10),active bone alkaline phosphatase(BALP),osteocalcin(OC)and C-terminal peptide crosslinking(S-CTX)of type I collagen in the observation group were higher than those in the control group(P＜0.05).The levels of procalcitonin(PCT)and tumor necrosis factor α(TNF-α)were lower than those in the control group(P＜0.05).Conclusion Dioxamine combined with ericoxib is effective in the treatment of patients with osteoporotic limb fractures.It can promote fracture healing and wound recovery by regulating inflammatory factors,inhibiting inflammatory response and regulating bone metabolism.
万方数据
维普
