Observation on the effect of non-invasive positive pressure ventilation assisted by coenzyme A in the treatment of acute exacerbation of chronic obstructive pulmonary diseases
Objective To analyze the effect of non-invasive positive pressure ventilation assisted by coenzyme A on acute exacerbation of chronic obstructive pulmonary disease(COPD).Methods 92 patients with acute COPD exacerbation from 2021 to 2023 were randomly divided into two groups.The control group(n=46)was treated with non-invasive positive pressure ventilation,and the study group(n=46)was treated with non-invasive positive pressure ventilation assisted by coenzyme A.Blood gas index,serum index and immune function were compared between the two groups.Results There was no significant difference in PaO2 and PaCO2 between the two groups before and after treatment(P＞0.05).After treatment,the pH of the study group was higher than that of the control group(P＜0.05).After treatment,iron and zinc levels in the study group were lower than those in the control group,CD4+,CD4+/CD8+levels were higher than those in the control group,and CD8+levels were lower than those in the control group(P＜0.05).Conclusion Coenzyme A assisted non-invasive positive pressure ventilation is more effective in the treatment of acute COPD exacerbation,which can improve the immune function and correct the content of iron and zinc in patients.
Coenzyme ANon-invasive positive pressure ventilationAcute exacerbation of COPDEffect observation
万方数据
维普
