Effect of plasma concentration monitoring of linezolid on efficacy and safety in children with severe Gram-positive bacteria infection
Objective To analyze the effect and safety of blood concentration monitoring of linezolid in children with severe Gram-positive bacteria infection.Methods A total of 80 children with severe Gram-positive bacterial infection admitted from January 2020 to December 2023 were randomly divided into two groups.The control group(40 cases)received routine linezolid treatment,and the study group(40 patients)initially received routine linezolid treatment,the blood concentration monitored was performed after 1 d of treatment,and the dose of linezolid was adjusted according to the blood concentration monitoring results combined with the comprehensive situation of the children,and the individualized treatment plan was given.The therapeutic effect and the clearance rate of Gram-positive bacteria in the two groups were evaluated,and the safety was analyzed.Results There was no significant difference in the levels of WBC,CRP,ALT,BUN and Cr between the two groups before treatment(P＞0.05);and there was no significant difference in the levels of ALT,BUN and Cr between the two groups after treatment(P＞0.05).After treatment,the levels of WBC and CRP in the study group were lower than those in the control group(P＜0.05).After treatment,29 casas of Gram-positive bacte-ria were cleared in the control group,with a clearance rate of 72.50%,and 36 cases of Gram-positive bacteria were cleared in the study group,with a clearance rate of 90.00%.The clearance rate of Gram-positive bacteria in the study group was higher than that in the control group(χ2=4.021,P=0.045).The total effective rate of the study group was higher than that of the control group(P＜0.05).The incidence of adverse reactions in the study group was lower than that in the control group(P＜0.05).Conclusion When treating children with severe Gram-positive bacteria infection,dose adjustment according to the results of linezolid blood concentration monitoring can improve the therapeutic effect of linezolid and the clearance rate of Gram-positive bacteria,reduce the level of inflammatory factors,and reduce the occurrence of adverse reactions.
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