依达拉奉联合超早期小骨窗开颅术治疗高血压脑出血的临床价值
Clinical value of edaravone combined with ultra-early small bone window craniotomy in the treatment of hypertensive cerebral hemorrhage
杨刚 1胡奇 1翟聪 1古运涛1
作者信息
- 1. 岳阳市中心医院神经外科,湖南岳阳 414000
- 折叠
摘要
目的 分析依达拉奉联合超早期小骨窗开颅术治疗高血压脑出血(HICH)的效果.方法 选取某院 2023 年 1 月～12 月收治的84 例HICH患者为研究对象,依照治疗方案差异分为两组,对照组(41 例)接受超早期小骨窗开颅术治疗,依达拉奉组(43 例)在对照组基础上联合依达拉奉治疗.比较两组治疗效果、脑血管功能参数[外周血管阻力(SVR)、脑血管平均血流量(Qmean)、动态阻力(DR)]、神经功能[美国国立卫生研究院卒中量表(NIHSS)评分、神经元特异性烯醇化酶(NSE)、胶质纤维酸性蛋白(GFAP)、髓鞘碱性蛋白(MBP)]及并发症发生情况.结果 与对照组(65.85%)比较,依达拉奉组总有效率(86.05%)更高(P＜0.05);治疗后,依达拉奉组SVR、DR均低于对照组,Qmean高于对照组(P＜0.05);治疗后,两组神经功能均得到改善,且依达拉奉组NIHSS评分及血清NSE、GFAP、MBP水平均低于对照组(P＜0.05);依达拉奉组并发症总发生率(9.30%)低于对照组(29.27%)(P＜0.05).结论 依达拉奉联合超早期小骨窗开颅术治疗HICH的效果显著,能有效改善患者脑血管功能、神经功能,且安全性高.
Abstract
Objective To analyze the effect of edaravone combined with ultra-early small bone window craniotomy in the treatment of hypertensive intracerebral hemorrhage(HICH).Methods 84 patients with HICH in a hospital from January 2023 to December 2023 were selected as the research objects and divided into two groups according to the difference of treatment plan.The control group(41 cases)was treated with ultra-early small bone window craniotomy,and the edaravone group(43 cases)was treated with edaravone on the basis of the control group.The therapeutic effect,cerebrovascular function parameters[systemic vascular resistance(SVR),mean cerebrovascular blood flow(Qmean),dynamic resistance(DR)],neurological function[ational institutes of health stroke scale(NIHSS)score,neuronal specific enolase(NSE),glial fibrillary acidic protein(GFAP),myelin basic protein(MBP)]and the incidence of complications were compared between the two groups.Results Compared with the control group(65.85%),the total effective rate of the edaravone group(86.05%)was higher(P＜0.05).After treatment,SVR and DR of the edaravone group were lower than those of the control group,and the Qmean was higher than that of the control group(P＜0.05).After treatment,neurological function was improved in both groups,and NIHSS score and the levels of serum NSE,GFAP and MBP in edaravone group were all lower than those in the control group(P＜0.05).The total incidence of complication rate of edaravone group(9.30%)was lower than that of the control group(29.27%)(P＜0.05).Conclusion Edalavone combined with ultra-early small bone window craniotomy is effective in the treatment of HICH,which can effectively improve cerebrovascular function and neurological function,and with high safety.
关键词
依达拉奉/小骨窗开颅术/超早期/高血压脑出血/神经功能/脑血管功能Key words
Edaravone/Small bone window craniotomy/Ultra-early/Hypertensive cerebral hemorrhage/Neurological function/Cerebrovascular function引用本文复制引用
出版年
2024
NETL
NSTL
万方数据