Neutralization effects screening experiment of 15 Lingnan Chinese herbal medicines on SARS-CoV-2 pseudovirus-infected cells
Objective To screen Lingnan characteristic Chinese herbal medicine for prevention and treatment of novel coronavirus pneumonia(COVID-19).Methods Using luciferase luminescence detection technology and the pseudo virus neutralization efficacy experiment method,15 unique Chinese herbal medicines from Lingnan region were screened and evaluated.Results Through the pseudovirus neutralization experiment,the herb Hypodermic fragrance displayed a pronounced viral neutralizing effect,inhibition rate(83.6%±4.0%),while the herbs Folium Psychotriae Rubrae and Microctis Folium showed a mild neutralizing effect,inhibition rate:(46.1%±3.2%)and(58.7%±5.9%),and the others did not exhibit obvious viral neutralization effect.Conclusion Lingnan characteristic authentic Chinese medicinal materials have potential application value in the clinical prevention and treatment of COVID-19.The results of this study provide reference for further drug screening and clinical medication.
Lingnan traditional Chinese medicineSARS-CoV-2Pseudovirus neutralization experiment
万方数据
维普
