首页|伊尼妥单抗、特瑞普利单抗联合白蛋白紫杉醇序贯治疗HER2阳性晚期乳腺癌一例

伊尼妥单抗、特瑞普利单抗联合白蛋白紫杉醇序贯治疗HER2阳性晚期乳腺癌一例

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目的 评估伊尼妥单抗、特瑞普利单抗联合白蛋白紫杉醇序贯治疗HER2 阳性晚期乳腺癌患者的安全性及疗效。方法 报告 1例HER2 阳性ⅢA期乳腺癌患者,术后因经济原因未采取抗HER2 辅助治疗。在发生多发转移后,患者参加进入临床试验,接受伊尼妥单抗、特瑞普利单抗联合白蛋白紫杉醇的 8 周期治疗,序贯伊尼妥单抗联合特瑞普利单抗维持治疗 12 周期。结果 患者接受 4 周期治疗后,疗效评估为完全缓解,目前无疾病进展生存期已超过 16 个月,治疗安全性表现良好。结论 对于HER2 阳性晚期乳腺癌,伊尼妥单抗、特瑞普利单抗联合化疗有希望成为一种新的一线治疗方案。
A case of HER2 positive advanced breast cancer treated by sequential therapy of initimumab,teripril monoclonal antibody and albumin paclitaxel
Objective To evaluate the safety and efficacy of sequential treatment with inetolimab,toripalimab combined with albumin paclitaxel in patients with HER-2 positive advanced breast cancer.Methods A case of HER2-positive stage ⅢA breast cancer was reported.The patient did not take anti-HER2 adjuvant treatment due to financial reasons after surgery.After the occurrence of multiple metastases,the patient entered the clinical trial,and received 8 cycles treatment of inetetamab,toripalimab and albumin paclitaxel.The sequential combination of inetetamab and toripalimab was sustained for 12 cycles.Results After 4 cycles of treatment,the patien was evaluated as complete response.The current progression-free survival has exceeded 16 months.The safety profile was good.Conclusion For HER2 positive advanced breast cancer,the combination of inetetamab,toripalimab and chemotherapy holds promise as a new first-line treatment option.

InetetamabToripalimabAlbumin paclitaxelAnti-HER2 therapyHER2-positive breast cancer

程鹏、黄俊婷、薛德威

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南阳医学高等专科学校第一附属医院肿瘤内科,河南南阳 473000

伊尼妥单抗 特瑞普利单抗 白蛋白紫杉醇 抗HER2治疗 HER2阳性乳腺癌

2024

中国处方药
南方医药经济研究所

中国处方药

影响因子:0.649
ISSN:1671-945X
年,卷(期):2024.22(9)