Analysis of adverse reaction reports of anti-infective drugs in a hospital from 2017 to 2022
Objective To explore the related factors and medication implications of adverse reactions of anti-infective drugs in a hospital from 2017 to 2022.Methods A retrospective analysis of 500 cases of anti-infective drug adverse reactions reported in a hospital from 2017 to 2022 was conducted.The age and gender distribution,route of administration,distribution of anti-infective drugs with adverse reactions,and adverse drug reactions were analyzed.Involved systems/organs and main clinical manifestations,types of adverse reactions reported and occupational distribution of reporters,etc.,and based on the analysis results,we put forward the use of anti-infective drugs.Results Among the 500 patients with adverse reactions to anti-infective drugs in a hospital,the male to female ratio was 1.07∶1,and the average age was(50.63±20.87)years old.The main route of administration of adverse reactions was intravenous drip,accounting for 85.60%.The adverse reactions of anti-infective drugs involved 21 categories and 89 varieties of anti-infective drugs.142 cases(28.40%)of quinolones were the top drug category.42 cases(8.40%)of levofloxacin were the single variety in the first place.The adverse reactions of anti-infective drugs involved multiple systems/organs,and systemic reactions accounted for the highest proportion in 121 cases(24.20%).The main clinical manifestations were anaphylactic shock in 74 cases(14.80%),allergic reaction in 38 cases(7.60%),thrombocytopenia in 36 cases(7.20%),and abnormal liver function in 29 cases(5.80%).Infectious drug adverse reactions were generally 460 cases(92.00%),accounting for a relatively large proportion,and 40 new and serious adverse reactions(8.00%),accounting for a relatively small proportion;Doctors reported 223 cases(44.60%),nurses reported 200 cases(40.00%),and these two categories accounted for a larger proportion.Conclusion This article analyzes the age and gender composition,route of administration,type and variety of adverse drug reactions,involved systems/organs and main clinical manifestations,types of adverse reactions reported and occupational distribution of reporters by analyzing the age and gender composition of patients with adverse reactions of anti-infective drugs.It suggests that when applying anti-infective drugs in clinical practice,targeted drugs must be given strictly according to the patient's physiological characteristics,specific conditions and the disease pathology itself,and more attention should be paid to the route of administration and speed of administration of anti-infective drugs,and real-time monitoring of the adverse reactions of patients during the drug process can be avoided or reduced to avoid the occurrence of adverse reactions of anti-infective drugs.
Anti-infective drugsAdverse drug reactionsReport analysis
万方数据
维普
