Efficacy and safety study of apatamide in combination with goserelin acetate in the treatment of prostate cancer with bone metastases
Objective To study the efficacy and safety of apatamide in combination with goserelin acetate in the treatment of prostate cancer with bone metastases.Methods A total of 60 patients with bone metastatic prostate cancer admitted from May 2021 to May 2023 were selected and divided into the control group(n=30)and the observation group(n=30)according to random number method.Both groups were treated with castration surgery,and the control group was treated with bicalutamide after surgery.The observation group received apaltamide after operation combined with goserrelin acetate.Both groups were treated for 3 months.The changes of serum markers,prostate symptom score and inflammatory factors before and after treatment were compared between the two groups to evaluate the clinical therapeutic effect and adverse reactions.Results After treatment,the levels of IGF-Ⅰ,VEGF and PSA in the observation group were lower than those in the control group(P＜0.05).After treatment,IPSS scores in the observation group were lower than those in the control group(P＜0.05).After treatment,the levels of IL-10 and total effective rate in the observation group were higher than those in the control group,and the levels of IL-6 and TNF-α were lower than those in the control group(P＜0.05).There was no significant difference in adverse reactions between the two groups(P＞0.05).Conclusion For patients with bone metastatic prostate cancer,apatamide combined with goserelin acetate can regulate the levels of serum markers and inflammatory factors,improve prostate symptoms,and has a good clinical efficacy and certain safety.
万方数据
维普
