Clinical study of Feixiankang Granule combined with pirfenidone in treating idiopathic pulmonary fibrosis of lung deficiency and collateral stasis type
Objective To investigate the clinical effect of Feixiankang Granules on patients with idiopathic pulmonary fibrosis(IPF)caused by lung deficiency and collateral stasis.Methods From November 2023 to May 2024,a total of 42 IPF patients admitted to the TCM department of The First Affiliated Hospital of Nanhua University and the pulmonary disease department of Hengyang TCM Hospital were included and randomly divided into the control group and the treatment group,with 21 cases in each group.The control group was given pirfenidone combined with placebo orally,and the treatment group was given pirfenidone combined with Feixiankang Granules orally.Both groups were treated for 3 months.After treatment,clinical efficacy were compared between the two groups,TCM syndrome scores,St.George's respiratory questionnaire(SGRQ)scores,6-minute walk distance(6-minute walk distance)scores,lung function,partial pressure of oxygen(PaO2),chest high resolution CT(HRCT)scores and serum type Ⅲ collagen(Ⅲ-C),type Ⅳ collagen(Ⅳ-C),superoxide dismutase(SOD),malondialdehyde(MDA)levels before and after treatment were compared between the two groups.Results The total effective rate of the control group and the treatment group was 71.43%and 90.47%,respectively,the difference was statistically significant(P＜0.05).Compared with the control group after treatment,TCM syndrome score,SGRQ symptom score and disease impact score,serum MDA,Ⅲ-C,Ⅳ-C levels in the treatment group were significantly decreased(P＜0.05).And diffusing capacity of the lungs for carbon monoxide(DLCO),PaO2 and serum SOD levels were significantly increased(P＜0.05).Conclusion The combination of Feixiankang Granules and pirfenidone has a synergistic effect,which can delay the progression of IPF,and its curative effect is better than pirfenidone monotherapy.The mechanism of action may be related to inhibiting MDA production,increasing SOD level and alleviating oxidative stress reaction.
Idiopathic pulmonary fibrosisLung deficiency and collateral stasisFeixiankang GranulePirfenidoneOxidative stress
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