Exploring the mechanism of action of oxymatrine in the treatment of thyroid cancer based on network pharmacology
Objective To explore the action mechanism of oxymatrine(OM)in the treatment of TC using network pharmacology.Methods Screening the relevant targets of OM for the treatment of TC through databases such as TCMSP;Obtain TC related disease targets through GEO gene expression database,TTD target database,Drugbank,GeneCards database,etc.,and construct Protein-Protein Interaction(PPI)through STRING database.Build a network diagram using Cytocape3.9.0 software;Apply DAVID database for GO and KEGG pathway analysis.Results 141 OM related drug targets and 1 405 TC related disease targets were obtained;Based on the degree value,core targets were selected,and the top ranked targets include tumor protein P53(TP53),protein kinase B(AKT1),mitogen activated protein kinase 3(MAPK3),tyrosine protein kinase(SRC),mitogen activated protein kinase 1(MAPK1),etc;GO functional enrichment shows that the biological processes of OM against TC mainly include cellular catabolism,B-lymphomatoma-2 protein family complexes,and protein kinase regulatory activity;The KEGG signaling pathway mainly involves the PI3K-Akt signaling pathway,HIF-1 signaling pathway,and JAK-STAT signaling pathway.Conclusion The mechanism of OM in treating TC involves multiple key targets and signaling pathways,and the cross effects between each target and pathway may inhibit inflammatory response and accelerate cancer cell apoptosis,thereby treat TC.
OxymatrineTCNetwork pharmacologySignal pathwayMechanism research
万方数据
维普
