Effect of Gulong Capsules combined with glucosamine hydrochloride capsules in the treatment of knee osteoarthritis and the impact on Lequesne index
Objective To investigate the clinical effects of Gulong Capsules combined with glucosamine hydrochloride capsules in the treatment of knee osteoarthritis(KOA)and the impact on Lequesne index.Methods Eighty patients with KOA who were admitted to the hospital from January 2022 to August 2023 were selected and divided into the control group and the observation group using a table of random numbers,with 40 cases in each group.The control group was treated with non-steroidal anti-inflammatory drugs(NSAIDs)while the observation group was treated with Gulong Capsules combined with glucosamine hydrochloride capsules.Both groups were treated continuously for 6 weeks according to standard drug usage.Clinical treatment effects in the two groups were calculated.The improvement in knee function and the changes in Lequesne index and inflammatory factors[interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)]were recorded.The incidence rates of adverse reactions were calculated.Results After 6 weeks of treatment,the total effective rate of the control group was 80.00%(32/40),lower than 95.00%(38/40)of the observation group.After 6 weeks of treatment,HSS scores of both groups increased and Lequesne index decreased.Meanwhile,increase and decrease in the observation group were greater(P＜0.05).After 6 weeks of treatment,the levels of IL-6 and TNF-α in both groups were lower than before treatment(P＜0.05),but there was no statistically significant between groups(P＞0.05).There was no significant difference between the two groups about adverse reactions(P＞0.05).Conclusion Compared to treatment with NSAIDs alone,the combined treatment with Gulong Capsules and glucosamine hydrochloride capsules can achieve better therapeutic effect on KOA.The latter can effectively reduce Lequesne index and improve knee function.However,its effect on inflammatory factors is comparable to that of treatment with NSAIDs alone.
Knee osteoarthritisGlucosamine hydrochloride capsulesGulong CapsulesLequesne index
万方数据
维普
