Predictive value of D-dimer and coagulation index testing in patients with acute coronary syndrome
Objective This study aims to investigate the predictive value of D-dimer and coagulation index testing in patients with acute coronary syndrome(ACS).Methods A retrospective analysis was conducted,involving 53 patients diagnosed with ACS who received treatment between January 1,2021,and December 31,2023,as the observation group.A control group of 47 healthy volunteers who underwent physical examinations during the same period was selected.Plasma levels of D-dimer,prothrombin time(PT),thrombin time(TT),activated partial thromboplastin time(APTT)and fibrinogen(FIB)were measured in both groups.The relationship between these indices and ACS was analyzed.The predictive value of D-dimer and coagulation indices in ACS patients was assessed using receiver operating characteristic(ROC)curve analysis.Results Serum levels of D-dimer,PT,TT,APTT and FIB were significantly higher in the observation group[(0.77±0.24)μg/ml,(13.79±3.31)s,(18.76±4.12)s,(42.15±3.85)s,(2.48±0.93)g/L]than in the control group[(0.41±0.11)μg/ml,(12.87±4.02)s,(16.32±7.29)s,(37.48±9.78)s,(1.84±0.47)g/L](P＜0.05).Logistic regression analysis indicated that overexpression of D-dimer,PT,TT,APTT and FIB might be factors contributing to the onset of ACS(OR＞1,P＜0.05).ROC curve analysis showed that the combined detection of D-dimer,PT,TT,APTT and FIB had the highest predictive value for the prognosis of ACS patients.Conclusion The combined detection of D-dimer,PT,TT,APTT and FIB demonstrates significant value in predicting the prognosis of ACS patients.
D-dimerCoagulation indexAcute coronary syndromeROC curvePredictive value
万方数据
维普
