Analysis of the effects of atorvastatin calcium combined with hyperbaric oxygen therapy on postoperative subdural effusion following cranial injury
Objective To evaluate the effects of atorvastatin calcium combined with hyperbaric oxygen therapy on postoperative subdural effusion in patients with cranial injuries.Methods From January 2020 to April 2024,a total of 80 patients with postoperative subdural effusion were included in a study.Patients were grouped by a balloting method;odd numbers formed the control group(40 patients)receiving hyperbaric oxygen therapy,and even numbers formed the experimental group(40 patients)receiving both atorvastatin calcium and hyperbaric oxygen therapy.The two groups were compared in terms of treatment efficacy,inflammatory factors[high-sensitivity C-reactive protein(hs-CRP),interleukin-1 β(IL-1β),tumor necrosis factor-α(TNF-α)],plasma brain injury biomarkers[human S100B protein(S-100B),neuron-specific enolase(NSE),myelin basic protein(MBP)],volume of subdural effusion,intracranial pressure recovery,CSS scores,and NIHSS scores.Results The total effective rate in the experimental group was 97.50%,significantly higher than 77.50%in the control group,with a statistically significant difference(χ2=7.314,P＜0.05).After 30 days of treatment,the levels of hs-CRP,IL-1β,and TNF-α in the experimental group were lower than those in the control group,with significant differences(P＜0.05).The levels of S-100B,NSE,and MBP in the experimental group were lower than those in the control group(P＜0.05).The intracranial pressure recovery time in the experimental group faster than those in the control group.Post-treatment,the subdural collection of fluid,CSS and NIHSS scores in the experimental group were(5.17±1.02)ml,(13.14±3.54)and(20.54±2.13)respectively,lower than(6.33±1.20)ml,(18.47±4.17)and(23.48±2.60)in the control group,with significant differences(P＜0.05).Conclusion Atorvastatin calcium combined with hyperbaric oxygen therapy in patients with postoperative subdural effusion following cranial injury not only improves the treatment of subdural effusion and accelerates the recovery of intracranial pressure but also effectively reduces levels of inflammatory factors and brain injury biomarkers,thereby facilitating neurological recovery.
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