摘要
目的 探讨阻塞性睡眠呼吸暂停(OSA)患者甘油三酯葡萄糖(TyG)指数与肱踝脉搏波速度(baPWV)的相关性.方法 选取2020年10月至2023年2月在中大医院江北院区及本部心脏康复中心行睡眠呼吸监测的患者205例,根据TyG指数四分位数将患者分为Q1、Q2、Q3、Q4组,根据睡眠呼吸低通气指数(AHI)将患者分为无OSA及轻度组、中重度组两组.评估各指标之间的关系.结果 在250例OSA患者中,TyG指数越高,男性和高血压病比例越高,身体质量指数(BMI)、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、空腹葡萄糖、尿酸、AHI、baPWV水平越高(P＜0.05),而年龄、平均血氧饱和度(SaO2)则越低(P＜0.05).与无OSA及轻度OSA患者比较,中重度OSA患者年龄、男性和高血压病比例及BMI、尿酸、AHI、baPWV水平更高,最低SaO2和平均SaO2水平更低(P＜0.05).Pearson相关性分析显示,TyG指数与AHI水平呈正相关(r=0.217,P=0.002).多元线性回归分析显示,年龄(β'=0.244,P＜0.01)、尿酸(β'=0.140,P=0.013)、高血压病(β'=0.128,P=0.016)、AHI(β'=0.342,P＜0.01)、TyG指数(β'=0.300,P＜0.01)是baPWV的影响因素,且AHI的影响最大,TyG指数其次.结论 TyG指数与OSA严重程度相关,TyG指数及OSA严重程度影响baPWV水平,运用TyG指数可能有助于识别OSA及动脉粥样硬化高风险患者.
Abstract
Objective To investigate the correlation between triglyceride-glucose(TyG)index and brachial-ankle pulse wave velocity(baPWV)in patients with obstructive sleep apnea(OSA).Methods From October 2020 to February 2023,205 patients who underwent sleep-breathing monitoring at the Jiangbei Campus and the Cardiac Rehabilitation Center of Zhongda Hospital were selected.According to the quartile of TyG index,the patients were divided into Q1,Q2,Q3 and Q4 groups,and according to the sleep apnea hypopnea index(AHI),the patients were divided into no OSA plus mild OSA group and moderate plus severe OSA group.The relationships between baPWV and each index were evaluated.Results Among the 250 OSA patients,the higher the TyG index,the higher the proportion of male and hypertension,the higher levels of the body mass index(BMI),total cholesterol,triacylgycerol,low-density lipoprotein cholesterol,fasting blood glucose,uric acid,AHI and baPWV(P＜0.05),while the lower values of the age and mean blood oxygen saturation(P＜0.05).Compared with no OSA plus mild OSA group,the age,the proportions of male and hypertension,and levels of BMI,uric acid,AHI,and baPWV increased,while the lowest and average blood oxygen saturation deseased in moderate plus severe OSA group(P＜0.05).Pearson correlation analysis showed a positive correlation between the TyG index and AHI levels(r=0.217,P=0.002).Multiple linear regression analysis showed that age(β'=0.244,P＜0.01),uric acid(β'=0.140,P=0.013),hypertension(β'=0.128,P=0.016),AHI(β'=0.342,P＜0.01)and TyG index(β'=0.300,P＜0.01)were the influencing factors for baPWV,and AHI had the greatest influence,followed by TyG index.Conclusion The TyG index is related to the severity of OSA,and TyG index and the severity of OSA affect the level of baPWV.The use of the TyG index may help identify OSA patients and those at high risk of arteriosclerosis.
基金项目
江苏省自然科学基金面上项目(BK20211167)
东南大学附属中大医院江北院区科研育苗基金(JB202105Q)
维普
万方数据