氨基酸代谢调控胃癌PI3K/AKT/mTOR信号通路的研究进展

Research progress of amino acid metabolism regulating PI3K/AKT/mTOR signaling pathway in gastric cancer

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中文摘要：在肿瘤微环境中,氨基酸是构成免疫细胞和肿瘤细胞的重要营养物质,其代谢过程中的部分蛋白质或关键酶有望成为肿瘤诊断标志物或治疗靶点.研究发现部分氨基酸含量在正常人和胃癌患者中存在明显差异.氨基酸代谢也被证实参与激活PI3K/AKT/mTOR通路,该通路是调节肿瘤细胞生长、增殖、分裂、自噬等活动的主要通路之一,氨基酸代谢可作为信号分子,通过激活该通路相关靶点来影响胃癌的发生发展及转归预后;此外,氨基酸代谢对于免疫细胞的激活和分化有着重要生物学作用,可以通过调控免疫细胞和免疫因子对肿瘤的免疫功能产生影响.

外文摘要：In the tumor microenvironment,amino acids are important nutrients constituting immune cells and tumor cells.Some proteins or key enzymes in the metabolism process are expected to become tumor diagnostic markers or therapeutic targets.It was found that the contents of some amino acids were obviously different between normal people and gastric cancer patients.Amino acid metabolism has also been confirmed to be involved in the activation of the PI3K/AKT/mTOR pathway,which is one of the main pathways regulating the growth,proliferation,division and autophagy of tumor cells.Amino acid metabolism can be used as a signal molecule to affect the occurrence,development and prognosis of gastric cancer by activating related targets of this pathway.In addition,amino acid metabolism plays an important biological role in the activation and differentiation of immune cells,which can affect the immune function of tumors by regulating immune cells and immune factors.

外文关键词：

Amino acid metabolismPI3K/AKT/mTOR pathwayGastric cancerImmunityAutophagyGlutamineLeucineArginineAspartate

作者：

易曼婷、李东芳

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作者单位：

湖南中医药大学中西医结合学院,湖南长沙 410208

湖南省肿瘤医院,湖南长沙 410013

关键词：

氨基酸代谢 PI3 K/AKT/mTOR通路胃癌免疫自噬谷氨酰胺亮氨酸精氨酸天冬氨酸

基金：

月恒全国名老中医药专家传承工作室湖南省科药联合基金项目湖南省中医药管理局重点项目湖南省中医药领军人才和学科带头人

项目编号：

湘财社[2014]119号2022JJ80077C2022007湘中医药[2022]4号

出版年：

2024

DOI：

10.13429/j.cnki.cjcr.2024.02.005

中国临床研究

中华预防医学会

中国临床研究

CSTPCD

影响因子：0.943

ISSN：1674-8182

年,卷(期)：2024.37(2)

参考文献量41