摘要
乳腺癌作为威胁我国女性生存的恶性肿瘤,其发病率逐年提升并呈年轻化趋势,控制肿瘤细胞的增殖、侵袭、转移是治疗的重点以及难点.死盒蛋白5(DDX5)作为一种调节RNA生物功能的加工因子,是参与调控RNA剪切、核糖体生物功能、转录、翻译的多维功能蛋白,可通过基因扩增、激活致癌因子、增强上皮间质转化、重组细胞骨架来促进乳腺癌增殖、侵袭、转移,同时可作为乳腺癌预后与复发的标志物.本文综述了DDX5在促进乳腺癌增殖、侵袭、转移中的作用,其对乳腺癌分型、预后、复发的意义以及现有的中药干预DDX5影响乳腺癌的临床报道,以期为乳腺癌新的靶向治疗思路提供新角度.
Abstract
Breast cancer,as a malignant tumor threatening the survival of women in China,its incidence rate is increasing year by year and showing a younger trend,control of cancer cell proliferation,invasion,metastasis is the focus and difficulty of treatment.DEAD-box polypeptide 5(DDX5),a processing factor regulating RNA biological function,is a multi-dimensional functional protein involved in regulating RNA splicing,ribosome biological function,transcription and translation.It can promote the proliferation,invasion and metastasis of breast cancer through gene amplification,activation of carcinogens,enhancement of epithelial mesenchymal transformation,and reorganization of cytoskeleton.It can also be used as a marker of prognosis and recurrence of breast cancer.This article reviews the role of DDX5 in promoting the proliferation,invasion and metastasis of breast cancer,its significance in the classification,prognosis and recurrence of breast cancer,and the clinical reports of existing Chinese medicine intervention DDX5 on breast cancer,which can provide a new perspective for the exploration of the etiology of breast cancer and new targeted therapy ideas.
基金项目
黑龙江省自然科学基金(LH2023H078)
黑龙江省自然科学基金(H2018054)
黑龙江省省级名中医专家传承工作室建设项目(黑中医药发[2020]55号)
黑龙江省卫生健康委科研项目(20220404010995)
NETL
NSTL
万方数据