Objective To analyze the epidemiological characteristics of notifiable infectious diseases in Tongzhou District of Nantong from 2017 to 2022,and provide scientific basis for developing targeted prevention and control strategies and measures.Methods Descriptive epidemiological methods were used to analyze the reported data of notifiable infectious diseases in Tongzhou District of Nantong from 2017 to 2022.Results From 2017 to 2022,a total of 25 379 cases of 26 types of notifiable infectious diseases were reported in Tongzhou District of Nantong,with an average annual incidence of 33.80 per 10 000.There were 27 deaths,with an average annual mortality rate of 0.04 per 10 000.Among the reported cases,the ratio of male to female reported incidence was 1.34∶1.The highest incidence of infectious diseases was observed in the age group under 10 years,mainly due to cases of varicella and hand-foot-mouth disease.The main occupational groups affected were farmers,preschool children,students,scattered children,and homemakers/unemployed individuals.Digestive tract infectious diseases such as hand-foot-mouth disease and other infectious diarrhea were mainly reported in summer,while respiratory tract infectious diseases such as varicella were more common in winter.The areas with the highest incidence were Xianfeng Street,Jinsha Street,and Xingren Town.The main types of infectious diseases reported were respiratory and intestinal tract infections.The top three reported diseases in terms of incidence rate were varicella,hand-foot-mouth disease,and syphilis.Conclusion In 2017-2022,the reported incidence of notifiable infectious disease in Tongzhou District of Nantong has showed a trend of fluctuating decline.However,it is still necessary to strengthen the monitoring and prevention of varicella and hand-foot-mouth disease,pay attention to the publicity and intervention of sexually transmitted diseases(such as syphilis),and maintain the incidence and mortality of notifiable infectious diseases at a low level compared to the national average.