溃疡性结肠炎多组学生物标志物的研究进展
Multiomics biomarkers in ulcerative colitis
商梦晗 1张兆美 2焦建新2
作者信息
- 1. 山东第二医科大学临床医学院,山东潍坊 261053;山东第二医科大学附属医院消化内一科,山东潍坊 261000
- 2. 山东第二医科大学附属医院消化内一科,山东潍坊 261000
- 折叠
摘要
随着对溃疡性结肠炎管理模式发生转变,治疗目标已从单纯的症状缓解转变为症状与内镜双重缓解.近年来,随着对炎症性肠病发病机制的深入研究,已从基因组学、蛋白质组学、微生物组学、转录组学、代谢组学等方面鉴定出诸多非侵入性生物标志物,且已应用于临床诊断、疗效评估和预后预测等,本文就已经应用于临床的以及新型的、潜在的生物标志物进行综述.
Abstract
With the paradigm shift in the management of ulcerative colitis,the treatment goal has shifted from symptomatic relief alone to dual relief of symptomatic and endoscopic.In recent years,with the in-depth study of the pathogenesis of inflammatory bowel disease,many non-invasive biomarkers have been identified from genomics,proteomics,microbiomics,transcriptomics,metabolomics,etc.These biomarkers have been applied to the diagnosis,efficacy evaluation and prognosis prediction of ulcerative colitis.This article reviews the biomarkers that have been applied in clinical practice,as well as novel and potential ones.
关键词
溃疡性结肠炎/微小RNA/英夫利西单抗/Toll样受体/肿瘤坏死因子-α/生物标志物/蛋白质组学/微生物组学/代谢组学/粪便钙卫蛋白/炎症性肠病/抗体Key words
Ulcerative colitis/MicroRNA/Infliximab/Toll-like receptor/Tumor necrosis factor-alpha/Biomarker/Proteomics/Microbiomics/Metabolomics/Feacal calportectin/Inflammatory bowel disease/Antibody引用本文复制引用
出版年
2024
NETL
NSTL
万方数据