Morphine is a classic opioid analgesic drug commonly used to treat chronic pain,cancer pain,neuropathic pain,etc.But repeated use can be addictive,this makes its clinical use severely limited.Morphine addiction has become a major global public health problem leading to the spread of some diseases.However,the mechanisms of morphine addiction are still not fully understood.An ion channel is a protein structure on the cell membrane,similar to a gate between inside and outside of the cell,that selectively allows some ions to enter and exit the cell.Current research shows that voltage-gated,ligand-gated and mechanically gated ion channels are all involved in the mechanism of morphine addiction.Therefore,this paper reviews the mechanism of voltage-gated,ligand-gated and mechanically gated ion channel for morphine addiction.
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