首页|细胞叠套结构对胰腺癌免疫治疗的影响

细胞叠套结构对胰腺癌免疫治疗的影响

Effect of cell-in-cell structures on immunotherapy of pancreatic cancer

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胰腺癌位列恶性肿瘤病死率的第七位,其治疗方法除了手术治疗,还有化疗、免疫治疗及靶向治疗.近年来,免疫治疗在多种恶性肿瘤的治疗中取得重大进展,在胰腺癌的治疗中也有所突破.细胞叠套结构(CICs)因其与各种生理和病理条件的相关性、与炎症和癌的起始和进展的关系以及在转化医学中的潜在意义而受到越来越多的关注.本文对CICs对癌细胞与免疫治疗的影响以及未来可能的作用位点进行综述,以期为胰腺癌的治疗提供新的思路.
Pancreatic cancer ranks the seventh in the mortality rate of malignant tumors.Its treatment methods include chemotherapy,immunotherapy and targeted therapy in addition to surgery.In recent years,immunotherapy has made significant progress in the treatment of various malignant tumors,and also made breakthroughs in the treatment of pancreatic cancer.Cell-in-cell structures(CICs)have received increasing attention due to their correlation with various physiological and pathological conditions,their relationship with the initiation and progression of inflammation and cancer,and their potential significance in translational medicine.This article reviews the impact of CICs on cancer cells and immunotherapy,as well as the possible action sites in the future,in order to provide new ideas for the treatment of pancreatic cancer.

Cell-in-cell structuresPancreatic cancerImmunotherapyCell cannibalismEntosisInterleukinCholesterolKeratinAlpha-cateninEarly growth response factor

刘兆雄、赵海平、王飞

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内蒙古医科大学第一临床医学院,内蒙古呼和浩特 010010

内蒙古医科大学附属医院肝胆外科,内蒙古呼和浩特 010010

细胞叠套结构 胰腺癌 免疫治疗 细胞自食 细胞套亡 白细胞介素 胆固醇 角蛋白 α-连环素 早期生长反应因子

内蒙古自治区科技计划内蒙古自治区高等学校科学技术重点研究项目内蒙古医科大学致远人才项目

YKD202202046NJZZ22651ZY0202035

2024

10.13429/j.cnki.cjcr.2024.04.024

中国临床研究
中华预防医学会

中国临床研究

CSTPCD
影响因子：0.943
ISSN：1674-8182
年,卷(期)：2024.37(4)
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