补体系统在脊髓损伤后神经修复中的作用进展
Effect progress of complement system in neural repair after spinal cord injury
张家诚 1叶双 1李从文 1薛淮 1许铁 2刘筱2
作者信息
- 1. 徐州医科大学,江苏徐州 221004
- 2. 徐州医科大学,江苏徐州 221004;徐州医科大学附属医院急诊创伤中心,江苏徐州 221006
- 折叠
摘要
脊髓损伤具有高致死率与高致残率的特点,其治疗一直是世界性难题.随着脊髓损伤研究的深入和治疗手段的进步,脊髓损伤患者的生存率有所提升,但其预后仍不理想.最新研究发现,免疫反应参与脊髓损伤后的病理变化和再生修复全过程,其中,补体系统在脊髓损伤的发生发展中扮演了重要角色.本文主要综述补体系统在继发性脊髓损伤及脊髓损伤后再生修复中的作用,包括补体系统的双刃剑作用,补体系统影响轴突再生与突触维持,及可能存在的信号通路,以期为脊髓损伤患者提供新的治疗思路.
Abstract
Spinal cord injury has the characteristics of high mortality and disability rates,and the treatment of spinal cord injury has been a worldwide problem.With the deepening of spinal cord injury research and the advancement of treatment methods,the survival rate of patients has improved,but the clinical efficacy is still not ideal.New research has found that the immune response is involved in the entire process of pathological changes and regeneration and repair after spinal cord injury.Among them,the complement system plays an important role in the occurrence and development of spinal cord injury.This article mainly reviews the role of the complement system in secondary spinal cord injury and regeneration and repair after spinal cord injury,including the double-edged sword effect of the complement system,the impact of the complement system on axonal regeneration and synaptic maintenance,and possible signaling pathways,with a view to improving the treatment of spinal cord injury,providing new treatment ideas.
关键词
脊髓损伤/补体/神经再生/轴突再生/免疫反应Key words
Spinal cord injury/Complement/Nerve regeneration/Axonal regeneration/Immune reaction引用本文复制引用
基金项目
徐州市卫生健康委彭城英才医学青年后备人才项目(XWRCHT20220035)
徐州市卫生健康委医学科技创新重点项目(XWKYHT20230055)
出版年
2024
NETL
NSTL
万方数据