抗阻力运动疗法对高血压病患者血管舒张功能及粥样硬化的作用

Effect of resistance exercise on vascular diastolic function and atherosclerosis in patients with hypertension

扫码查看

原文链接

NETL
NSTL
万方数据

中文摘要：目的探讨抗阻力运动疗法对高血压病患者自我管理能力、血管舒张功能与粥样硬化的改善作用.方法将2019年12月到2022年1月于国药东风总医院诊治的160例高血压患者纳入研究,采用随机数字表法将患者分为研究组(n=80)及传统组(n=80).传统组在药物治疗的基础上予常规有氧运动训练,研究组在传统组基础上予抗阻力运动训练,两组患者均予干预3个月,比较并分析训练前后患者血管舒张功能与粥样硬化变化情况.结果研究组和传统组患者训练后的收缩压及舒张压与训练前对比显著下降(P＜0.05),且研究组显著低于传统组(P＜0.05).两组训练后的自我管理能力评分(45.28±3.17,40.10±2.22)与训练前对比(31.48±3.18,31.54±2.58)显著升高,且研究组显著高于传统组(t=11.972,P＜0.05).两组患者训练后的血清脂蛋白相关磷脂酶2(Lp-PLA2)、同型半胱氨酸(Hcy)水平较前显著下降,且研究组显著低于传统组(P＜0.05).两组患者训练后的动脉内径变化率、非内皮依赖性血管舒张功能动脉内径变化率与训练前对比显著升高,且研究组显著高于传统组(P＜0.05).两组患者训练后颈动脉内膜中层厚度与训练前对比差异无统计学意义,且研究组和传统组差异无统计学意义(P＞0.05).结论抗阻力运动可改善高血压患者血管舒张功能与粥样硬化状况,抑制Lp-PLA2和Hcy的表达,持续降低血压,提高患者的自我管理能力.

外文摘要：Objective To investigate the effect of resistance exercise on self-management ability,vascular diastolic function and atherosclerosis in patients with hypertension.Methods A total of 160 patients with hypertension treated in Sinopharm Dongfeng General Hospital from December 2019 to January 2022 were enrolled in this study.Patients were divided into study group(n=80)and traditional group(n=80)by random number table method.The traditional group was given routine aerobic exercise training based on drug therapy,and the research group was given resistance exercise training based on traditional therapy.Patients in both groups received intervention for 3 months,and the changes of vascular endothelial diastolic function and atherosclerosis were compared and analyzed before and after training.Results After training,the systolic blood pressure and diastolic blood pressure of the two groups decreased significantly compared with those before training(P＜0.05),and the study group was significantly lower than the traditional group(P＜0.05).The scores of self-management ability(45.28±3.17,40.10±2.22)in the study group and traditional group were significantly higher than those before training(31.48±3.18,31.54±2.58);The score of self-management ability in study group was significantly lower than that in traditional group(t=141.972,P＜0.05).The serum levels of lipoprotein-associated phospholipase 2(Lp-PLA2)and homocysteine(Hcy)in two groups decreased significantly compared with those before training(P＜0.05),and the levels of serum Lp-PLA2 and Hcy in the study group were significantly higher than those in the traditional group(P＜0.05).The change rate of artery diameter and the change rate of artery diameter of endothelium-dependent vasodilation function in the two groups were significantly higher than those before training,and the study group was significantly higher than the traditional group(P＜0.05).There was no significant difference in carotid intima-media thickness between the two groups after training and before training,and there was no significant difference between the study group and the traditional group(P＞0.05).Conclusion Resistance exercise can improve vascular endothelial relaxation function and atherosclerosis status,inhibit the expression of Lp-PLA2 and Hcy,reduce blood pressure continuously,and improve the self-management ability of patients with hypertension.

外文关键词：

Resistance exerciseHypertensionVascular diastolic functionAtherosclerosisLipoprotein-associated phospholipase 2Homocysteine

作者：

李云鹏、王皓、刘桐桐、马秋阳、杨汉东、陈俊

展开 >

作者单位：

湖北医药学院附属国药东风总医院心血管内科,湖北十堰 442008

十堰国药东风口腔医院,湖北十堰 442008

关键词：

抗阻力运动高血压血管舒张功能粥样硬化脂蛋白相关磷脂酶2 同型半胱氨酸

基金：

湖北省卫生健康委员会科研立项十堰市市级引导性科研项目国药东风总医院卓越计划(院内项目)青年人才项目立项

项目编号：

WJ2019F06721Y862022Q01

出版年：

2024

DOI：

10.13429/j.cnki.cjcr.2024.06.010

中国临床研究

中华预防医学会

中国临床研究

CSTPCD

影响因子：0.943

ISSN：1674-8182

年,卷(期)：2024.37(6)