肠道菌群对肝癌作用机制的研究进展
Research progress on the mechanism of action of gut microbiota on hepatocellular carcinoma
胥华泰 1应培均 1杨季红 1程树杰1
作者信息
- 1. 河北大学附属医院肝胆外科,河北保定 071000
- 折叠
摘要
肝细胞癌在全球恶性肿瘤中的发病率和死亡率持续升高.近年来,研究表明肠道菌群与肝癌的发生和发展密切相关.肠道菌群是人体内的一种微生物群落,它在许多生理和病理过程中发挥着关键作用.本文综述了肠道菌群与肝癌之间的联系,包括机制、影响因素和治疗前景,以期为肝癌的预防和治疗提供新的思路.
Abstract
Hepatocellular carcinoma(HCC)has a high incidence rate among the malignant tumors reported in the world,and its incidence rate and mortality continue to rise.In recent years,researches have shown that the gut microbiota is closely related to the occurrence and development of HCC.The gut microbiota is a microbial community within the human body that plays a crucial role in many physiological and pathological processes.This paper reviews the relationship between gut microbiota and HCC,including mechanisms,influencing factors,and therapeutic prospects,in order to provide new ideas for the prevention and treatment of HCC.
关键词
原发性肝癌/肠道菌群/瘤内微生物/肿瘤微环境/肠—肝轴/肝细胞癌Key words
Primary liver cancer/Gut microbiota/Intratumoral microorganisms/Tumor microenvironment/Immune response/Intestinal hepatic axis/Hepatocellular carcinoma引用本文复制引用
基金项目
河北省2023年政府资助临床医学优秀人才培养项目(ZF2023230)
出版年
2024
NETL
NSTL
万方数据