胰腺再生蛋白在糖尿病预警及诊疗中的应用价值
Application of pancreatic regenerating protein in early warning and diagnosis of diabetes mellitus
黄楠 1朱慧敏 2王慧 1黄䮎 1李玲1
作者信息
- 1. 东南大学附属中大医院内分泌科,江苏南京 210009;东南大学医学院,江苏南京 210009
- 2. 南京医科大学附属淮安第一医院电生理室,江苏淮安 223000
- 折叠
摘要
胰腺再生(REG)蛋白是由再生基因编码的一组钙依赖性凝集素超家族蛋白.REG蛋白家族作为具有多种功能的分泌型生长因子,在营养代谢、抗凋亡、抗纤维化和抗炎抗菌等方面起着调节作用.自1979年被首次发现至今,REG蛋白家族被证实与糖尿病、炎症和肿瘤等多种疾病息息相关.REG蛋白家族的多种亚型参与糖尿病的不同发病机制.本文旨在综述REG蛋白家族的起源、结构特征、分布模式、在各种类型糖尿病中的发病机制和治疗调控作用,探讨REG蛋白家族在糖尿病预警、诊断、治疗和预后方面的潜在临床应用价值,以期未来更广泛地应用于治疗靶标和生物标志物领域.
Abstract
Pancreatic regenerating(REG)protein belongs to the calcium-dependent lectin superfamily,and is encoded by regenerating gene.As secreted growth factors with multiple functions,REG protein family plays a regulatory role in nutrient metabolism,anti-apoptosis,anti-fibrosis,anti-inflammation and antibacterial.Since 1979,REG protein family has been found to be associated with various diseases,such as diabetes,inflammation and cancer.Several subtypes of REG proteins are involved in different pathogenesis of diabetes.The purpose of this study is to review the origin,structural characteristics,distribution patterns of REG protein family and its pathogenesis and therapeutic regulation in different types of diabetes,and to explore the potential application value of REG protein family in the early warning.diagnosis,treatment and prognosis of diabetes,with a view to its wider application in the fields of therapeutic targets and biomarkers in the future.
关键词
胰腺再生蛋白/胰岛β细胞再生/糖尿病/胰腺外分泌糖尿病/临床预警Key words
Pancreatic regenerating protein/Regeneration of islet beta cell/Diabetes mellitus/Diabetes of exocrine pancreas/Clinical early warning引用本文复制引用
出版年
2024
NETL
NSTL
万方数据