维生素D与儿童和青少年2型糖尿病发病分子机制研究进展

Research progress of the molecular mechanism between vitamin D and type 2 diabetes mellitus in children and adolescents

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中文摘要：2型糖尿病(T2DM)在全球的发病率不断上升.随着儿童肥胖率的增加,T2DM的发病率在儿童当中也呈现出上升的趋势.与成年患者相比,儿童T2DM患者血糖控制持久性更差,且更容易出现并发症.近年来,研究发现成人患者中维生素D缺乏与T2DM发病密切相关,在儿童与青少年群体中的研究报道也越来越多.机制方面,维生素D具有提高胰岛素敏感性和调节胰岛素分泌的作用,维生素D调节胰岛的敏感性可能与肾素—血管紧张素—醛固酮系统(RAAS)、过氧化物酶体增殖物激活受体(PPAR)及氧化应激系统等通路有关,也可通过调节蛋白激酶A(PKA)、L型电压依赖性钙通道(L-type VDCC)、磷脂酶C(PLC)、ATP敏感性钾通道(KATP)等信号分子刺激胰岛素的分泌.本文旨在阐述维生素D缺乏与儿童和青少年T2DM发病关系及相关分子机制,为儿童和青少年T2DM的预防和治疗提供参考.

外文摘要：The incidence of type 2 diabetes mellitus(T2DM)is increasing globally.With the growing prevalence of obesity in childhood,the incidence of T2DM is also on the rise among children.Children with T2DM have worse persistent ability in glycemic control and are more prone to complications than adults.In recent years,some studies have found that vitamin D deficiency is closely related to T2DM in adult patients,and its relationship in children and adolescents has also been reported by more and more studies.In terms of mechanism,vitamin D posses the ability of improving insulin sensitivity and regulating insulin secretion,the former has a relationship with renin angiotensin aldosterone system(RAAS),peroxisome proliferator activated receptor(PPAR),oxidative stress system and other pathways,and later with protein kinase A(PKA),L-type voltage-dependent calcium channel(L-type VDCC),phospholipase C(PLC),ATP sensitive potassium channel(KATP)and other signaling molecules.Thus,the review aims to explore the relationship between the deficiency of vitamin D and the incidence of T2DM in children and adolescents and its possible molecular mechanism,so as to provide a reference for the prevention and treatment of T2DM in children and adolescents.

外文关键词：

Type 2 diabetesVitamin DChildren and adolescentsRenin angiotensin aldosterone systemPeroxisome proliferator activated receptorProtein kinase AL-type voltage-dependent calcium channelPhospholipase CATP sensitive potassium channel

作者：

朱亭、顾威、刘长伟

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作者单位：

南京医科大学附属儿童医院临床营养科,江苏南京 210008

南京医科大学附属儿童医院内分泌科,江苏南京 210008

关键词：

2型糖尿病维生素D 儿童和青少年肾素—血管紧张素—醛固酮系统过氧化物酶体增殖物激活受体蛋白激酶A L型电压依赖性钙通道磷脂酶C ATP敏感性钾通道

出版年：

2024

DOI：

10.13429/j.cnki.cjcr.2024.07.006