T cells are closely associated with tumor development and the homeostasis of the tumor microenvironment(TME).The co-receptors of immune checkpoints on the surface of T cells collectively regulate immune responses and can inhibit or kill tumor cells by secreting various substances,correcting and restoring impaired anti-tumor immune responses.In recent years,there has been some progress in targeted T cell therapy,but some new immune test targets are still being studied.This article focuses on the role of T cells in the regulation of colorectal cancer(CRC)and TME,the mechanism of immune resistance to CRC and its targeted therapy,and discusses the relevant effects of T cells on the occurrence and development of CRC and the application prospect of targeted T cell therapy for CRC.
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