Objective To explore the therapeutic effect of Ginkgo biloba tablets on patients with unstable angina and their impact on fibroblast growth factor 4(FGF-4).Methods From January 2022 to September 2023,360 patients with unstable angina who received treatment in Lianyungang First People's Hospital were selected and divided into low-risk group(Gensini score 1-30,n=112),medium risk group(Gensini score 31-60,n=156),and high-risk group(Gensini score 61-90,n=92)based on Gensini score.Each group of patients were randomly divided into an observation group and a control group.The control group was treated with standard treatment plan for coronary heart disease,while the observation group was treated with Ginkgo biloba tablets in addition to the control group.After 4 weeks of treatment,the levels of FGF-4 and inflammatory factors,the frequency and duration of angina attacks,and the severity of unstable angina(Braunwald classification)were compared between the different groups.Results After treatment,the peripheral serum FGF-4 levels of patients in the low-risk observation group and the medium risk observation group were higher than their corresponding control groups(P＜0.05).The high-risk observation group showed an increasing trend in FGF-4 levels compared to its control group,but the difference was not statistically significant(P＞0.05).The average levels of tumor necrosis factor(TNF)-α,interleukin(IL)-2,and IL-6 in the three observation groups were lower than those in the corresponding control group(P＜0.05).After treatment,the frequency and duration of angina attacks in the low-risk observation group and the medium risk observation group were lower than those in the corresponding control group(P＜0.05),while there was no statistically significant difference between the high-risk observation group and its control group(P＞0.05).There was no statistically significant difference in the incidence of adverse reactions between the observation group and the control group after treatment(P＞0.05).Conclusion Ginkgo biloba leaves extract tablets can improve the clinical efficacy and alleviate clinical symptoms in patients with unstable angina pectoris.Its mechanism may be related to its anti-inflammatory effect by increasing FGF-4 levels,thereby reducing the levels of TNF-α,IL-2,and IL-6 inflammatory factors.
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