中国临床研究2024,Vol.37Issue(9) :1432-1437.DOI:10.13429/j.cnki.cjcr.2024.09.024

基因检测在胰腺癌全身治疗中的研究进展

Research progress of gene detection in systemic therapy of pancreatic cancer

李根 白亦焘 阿永俊
中国临床研究2024,Vol.37Issue(9) :1432-1437.DOI:10.13429/j.cnki.cjcr.2024.09.024

基因检测在胰腺癌全身治疗中的研究进展

Research progress of gene detection in systemic therapy of pancreatic cancer

李根 1白亦焘 1阿永俊1
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作者信息

  • 1. 昆明医科大学第二附属医院肝胆胰外科,云南昆明 650106
  • 折叠

摘要

胰腺癌是常见的高度恶性的消化道肿瘤,发病部位及疾病特征导致其治疗难度极大,并且胰腺癌的分子多样性所导致的异质性,可能是迄今为止系统治疗效果不佳的原因.除手术治疗外,辅助药物仍是胰腺癌患者的治疗的重要方式.多项研究表明,胰腺癌患者手术后规律行辅助化疗可明显获益.基因检测是近年来兴起的胰腺癌辅助检查方法,可指导胰腺癌患者术后选择更加合适的治疗药物.本文重点探讨基因检测对胰腺癌治疗药物选择的意义.

Abstract

Pancreatic cancer is a common highly malignant digestive tract tumor.Due to its location and disease characteristics,it presents significant challenges in treatment.The molecular diversity of pancreatic cancer contributes to its heterogeneity,which may key reasons for the poor efficacy of systemic treatments to date.Apart from surgical interventions,adjuvant therapy remains crucial for pancreatic cancer patients.Several studies have indicated that regular adjuvant chemotherapy following surgery can significantly benefit patients.Genetic testing has emerged in recent years as a new auxiliary diagnostic method for pancreatic cancer,guiding postoperative selection of more appropriate treatment drugs.This article focuses on the significance of genetic testing in the selection of therapeutic drugs for pancreatic cancer.

关键词

胰腺癌/基因检测/化疗/药物治疗/氟尿嘧啶/吉西他滨/基因突变/KRAS/TP53/SMAD4/CDKN2A

Key words

Pancreatic cancer/Genetic testing/Chemotherapy/Drug therapy/Fluorouracil/Gemcitabine/Gene mutation/KRAS/TP53/SMAD4/CDKN2A

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出版年

2024
中国临床研究
中华预防医学会

中国临床研究

CSTPCD
影响因子:0.943
ISSN:1674-8182
参考文献量10
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