中国临床研究2024,Vol.37Issue(9) :1438-1442.DOI:10.13429/j.cnki.cjcr.2024.09.025

术后急性肾损伤的研究现状与进展

Current status and progress in research on postoperative acute kidney injury

刘斌 逯英杰 耿玉涵 庞瑶 朱自江
中国临床研究2024,Vol.37Issue(9) :1438-1442.DOI:10.13429/j.cnki.cjcr.2024.09.025

术后急性肾损伤的研究现状与进展

Current status and progress in research on postoperative acute kidney injury

刘斌 1逯英杰 2耿玉涵 1庞瑶 2朱自江3
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作者信息

  • 1. 宁夏医科大学,宁夏银川 750000;甘肃省人民医院胸外二科,甘肃兰州 730000
  • 2. 甘肃省人民医院胸外二科,甘肃兰州 730000
  • 3. 甘肃省中心医院胸外科,甘肃兰州 730000
  • 折叠

摘要

术后急性肾损伤(AKI)是大手术常见并发症之一,与死亡率和长期不良事件相关.改善全球肾脏病预后组织(KDIGO)提出AKI的定义,将血肌酐的升高和尿量减少作为诊断标准.然而,这种传统的诊断标准是不准确的,需要通过新的生物标志物协助诊断.术后发生AKI的危险因素可以从术前、术中和术后多个方面考虑,通过优化围手术期危险因素,从而减少AKI的发生.AKI的治疗方式有限,仍以对症支持治疗为主,因此早期识别、诊断和治疗是改善患者预后的关键步骤.

Abstract

Postoperative acute kidney injury(AKI)is one of the common complications of major surgery,associated with mortality and long-term adverse events.The Kidney Disease:Improving Global Outcomes(KDIGO)has proposed the definition of AKI,using elevated blood creatinine and decreased urine output as diagnostic criteria.However,this traditional diagnostic standard is inaccurate and requires the assistance of new biomarkers for diagnosis.The risk factors for postoperative AKI can be considered from various aspects,including preoperative,intraoperative,and postoperative factors.By optimizing perioperative risk factors,the occurrence of AKI can be reduced.The treatment methods for AKI are limited and still focus on symptomatic supportive treatment.Therefore,early identification,diagnosis,and treatment are key steps in improving patient prognosis.

关键词

急性肾损伤/发病机制/生物学标志物/半胱氨酸蛋白酶抑制剂C/中性粒细胞明胶酶相关脂质运载蛋白/肾损伤分子-1/白细胞介素/肝型脂肪酸结合蛋白/基质金属蛋白酶

Key words

Acute kidney injury/Pathogenesis/Biomarkers/Cysteine protease inhibitor C/Neutrophil gelatinase-associated lipocalin/Kidney injury molecule-1/Interleukin/Liver fatty acid binding protein/Matrix metalloproteinases

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基金项目

甘肃省人民医院优秀硕/博士生培育计划(22GSSYD-80)

出版年

2024
中国临床研究
中华预防医学会

中国临床研究

CSTPCD
影响因子:0.943
ISSN:1674-8182
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