Objective To observe the application effects of early cardiac rehabilitation combined with psychological care intervention after percutaneous coronary intervention(PCI)in patients with acute coronary syndrome(ACS).Methods A total of 108 ACS patients who underwent PCI at the Huai'an First People's Hospital from October 2020 to October 2022 were selected.They were randomly divided into the combined group(routine care+early cardiac rehabilitation+psychological nursing intervention)and the control group(routine care),with 54 patients in each group.The study compared the changes in cardiac function,depression levels,self-management ability,medication adherence,quality of life,and major adverse cardiovascular events(MACE)before and after intervention.Results After intervention,the left ventricular ejection fraction(LVEF)in the combined group was higher than that in the control group.The 6-minute walk distance(6MWD)was longer,and the N-terminal pro-B-type natriuretic peptide(NT-proBNP)was lower in the combined group compared to the control group(P<0.05).The combined group showed lower scores on the Patient Health Questionnaire-9(PHQ-9)compared to the control group.Scores of the Coronary Heart Disease Self-Management Scale(CSMS)and Morisky Medication Adherence Scale-8(MMAS-8)were higher in the combined group(P<0.05).Physical function,psychological function,social function,and material life state scores were higher in the combined group than in the control group(P<0.05).The incidence of MACE in the combined group was lower than that in the control group(5.77%vs 19.23%,x2=4.308,P=0.038).Conclusion Early cardiac rehabilitation combined with psychological care intervention can improve cardiac function,mental status,self-management ability,medication adherence,and quality of life in ACS patients after PCI,reducing the occurrence of MACE.