目的 系统评价支气管镜下灌洗辅助治疗儿童支原体肺炎的临床疗效,为临床治疗提供参考.方法 检索中国知网(CNKI)、万方、维普、中国生物医学文献数据库(CBM)、PubMed、Embase以及Web of Science数据库,检索支气管镜灌洗辅助治疗儿童支原体肺炎的随机对照试验研究,根据Cochrane评价手册对符合纳入标准的文献进行评价,使用Stata 16.0软件进行Meta分析.结果 共纳入22项随机对照研究,均为中文文献,合计1 774例患儿.Meta分析结果显示,支气管镜灌洗辅助治疗儿童支原体肺炎能显著提高有效率[RR=1.22,95％CI(1.17,1.26),P＜0.01],缩短患儿住院时间[WMD=-3.23,95％CI(-3.64,-2.82),P＜0.01]、啰音消失时间[WMD=-2.67,95％CI(-3.12,-2.21),P＜0.01]、体温恢复正常时间[WMD=-1.57,95％CI(-1.84,-1.29),P＜0.01]和咳嗽消失时间[WMD=-2.75,95％CI(-3.40,-2.11),P＜0.01].结论 支气管镜灌洗辅助治疗儿童支原体肺炎较常规治疗可显著提高临床有效率,改善患儿症状.
Abstract
Objective To systematically evaluate the clinical efficacy of bronchoscopic lavage-assisted treatment of Mycoplasma pneumonia(MP)in children,providing references for clinical treatment.Methods China National Knowledge Infrastructure(CNKI),Wanfang,VIP,China Biology Medicine disc(CBM),PubMed,Embase and Web of Science were searched for randomized controlled trials of bronchoscopic lavage-assisted treatment of MP in children.Studies meeting inclusion criteria were evaluated according to the Cochrane Review manual,and Meta-analysis was performed using Stata 16.0 software.Results A total of 22 randomized controlled trials were included,all in Chinese,with a tolal of 1 774 children.Meta-analysis showed that bronchoscopic lavage-assisted treatment of MP in children significantly increased the effective rates[RR=1.22,95％CI(1.17,1.26),P＜0.01],and shortened the hospital stay[WMD=-3.23,95％CI(-3.64,-2.82),P＜0.01],time to disappearance of rales[WMD=-2.67,95％CI(-3.12,-2.21),P＜0.01],time to return to normal temperature[WMD=-1.57,95％CI(-1.84,-1.29),P＜0.01],time to disappearance of cough[WMD=-2.75,95％CI(-3.40,-2.11),P＜0.01].Conclusion Bronchoscopic lavage-assisted treatment of MP in children can significantly improve the clinical effective rate and the symptoms of children.
关键词
支气管镜灌洗/支原体肺炎/随机对照试验/儿童/Meta分析
Key words
Bronchoscopic lavage/Mycoplasma pneumonia/Randomized control trial/Children/Meta-analysis
维普
万方数据