艾司氯胺酮临床应用的研究进展
Research progress on the clinical application of esketamine
姜乐乐 1杜晓宣1
作者信息
- 1. 新疆医科大学第六附属医院麻醉科,新疆乌鲁木齐 830000
- 折叠
摘要
艾司氯胺酮是外消旋氯胺酮的S-对映异构体,具有与氯胺酮相似的药理学机制,且具有起效快、代谢快、对循环和呼吸功能影响小以及镇静镇痛作用较强等优点.因此,艾司氯胺酮在精神疾病、围术期麻醉和急救与危重症等多学科和领域的应用广泛.本文综述了艾司氯胺酮的药理学特点、作用机制、临床应用现状以及不良反应,以期为其应用和研究提供参考.
Abstract
Esketamine is the S-enantiomer of racemic ketamine,which has a similar pharmacological mechanism to ketamine.Esketamine has the advantages of fast onset,fast metabolism,little impact on circulatory and respiratory functions,and strong sedative and analgesic effects.Therefore,esketamine is widely used in multidisciplinary and field areas such as psychiatric disorders,perioperative anesthesia,first aid and critical illness increasingly.This article reviews the pharmacological characteristics,mechanism of action,clinical application status and adverse reactions of esketamine,which aims to provide a reference for application and research.
关键词
艾司氯胺酮/围术期麻醉/精神疾病/急救/危重症/抑郁/镇痛/难治性癫痫Key words
Esketamine/Perioperative anesthesia/Mental illness/First aid/Critical illness/Depression/Analgesia/Refractory epilepsy引用本文复制引用
出版年
2024
NETL
NSTL
万方数据