慢性肾脏病合并肌肉减少症发病机制的研究进展
Research progress on the pathogenesis of chronic kidney disease combined with sarcopenia
李博浩 1窦一田 2张莉 3张诗元4
作者信息
- 1. 天津中医药大学研究生院,天津 301617
- 2. 天津中医药大学第一附属医院肾病科,天津 300381
- 3. 宣汉县人民医院,四川达州 636150
- 4. 天津中医药大学第一附属医院急症科,天津 300381
- 折叠
摘要
肌肉减少症的发生与慢性肾脏病密切相关.近年来,慢性肾脏病患者肌肉减少症的发病率明显增高,影响着疾病的预后转归.近年来研究发现,慢性肾脏病合并肌肉减少症的发生与慢性炎症、氧化应激、线粒体功能障碍、激素水平异常、胰岛素抵抗、血管紧张素Ⅱ(Ang Ⅱ)过多、维生素D缺乏、血液透析、运动障碍等因素有关.本文对其发病机制予以综述.
Abstract
The occurrence of sarcopenia is closely related to chronic kidney disease.In recent years,the incidence rate of sarcopenia in chronic kidney disease patients has increased significantly,affecting the prognosis of the disease.In recent years,studies have found that the occurrence of sarcopenia in chronic kidney disease is related to factors such as chronic inflammation,oxidative stress,mitochondrial dysfunction,abnormal hormone levels,insulin resistance,excessive angiotensin Ⅱ,vitamin D deficiency,hemodialysis,and movement disorders.This article provides a review of its pathogenesis.
关键词
慢性肾脏病/肌肉减少症/慢性炎症/氧化应激/线粒体功能障碍/胰岛素抵抗/血管紧张素Ⅱ/维生素D缺乏/血液透析/运动障碍Key words
Chronic kidney disease/Sarcopenia/Chronic inflammation/Oxidative stress/Mitochondrial dysfunction/Insulin resistance/Angiotensin Ⅱ/Vitamin D deficiency/Hemodialysis/Movement disorders引用本文复制引用
出版年
2024
NETL
NSTL
万方数据