Objective To investigate the relationship between the absence or short nasal bone and chromosome abnormality.Methods Retrospective analysis of 220 cases of pregnancy prenatal system ultrasound screening diagnosed as abnormal nasal bone development,compare the loss of nasal bone and short fetal chromosome abnormalities detection rate,and compare the differences with other structural abnormalities or ultrasond soft index abnormalities.Results The detection rate of chromosome abnormalities in 220 fetuses with abnormal nasal bone develoment was 8.64％(19/220).The detection rate of chromosome abnormalities in fetuses with abnormal nasal bone development was significantly higher than that of isolated fetuses(21.57％VS 4.73％),and the difference was statistically significant(P＜0.05).There was no significant difference in the detection rate of lsolated nasal bone development abnomalities,nasal bone development abnormalities and other ultrasoud abnormalities(P＞0.05).Conclusion The incidence of fetal nasal bone absence or short chromosome abnormality is increased,the incidence of chromosomal abnormalities is higher when combined with other structural malformations or ultrasound soft index abnormalities,absence or short nasal bone was detected by prenatal ultrasound,detailed ultrasound examination should be performed for other structural and ultrasound soft indicators,and prenatal genetic testing should be recommended to exclude chromosomal genetic abnormalities,regardless of other structural abnormalities or ultrasound soft indicators.
Abnormal nasal bone development,Nasal bone absenceNasal bone shortChromosome abnormality
维普
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