Objective To explore the relationship between Y chromosome microdeletions,karyotypes and male semen quality in male infertile patients,so as to provide scientific basis for the clinical treatment of male infertile patients and the selection of reasonable reproductive assistance techniques and eugenics.Methods Retrospective analysis of 210 male infertile patients who visited the Reproductive Medicine Center of Northern Guangdong People's Hospital from January 2019 to December 2023,divided into azoospermia group,severe oligozoospermia group,and oligozoospermia group.36 healthy males were selected as the control group during the same period.All patients underwent routine semen analysis,and using PCR fluorescent probe method for Y chromosome microdeletion and G-banding techniques for chromosome karyotype analysis.Results Among 210 infertile males,11 cases of Y chromosome microdeletion abnormalities,29 cases of chromosomal karyotype abnormalities,3 cases of chromosomal normal polymorphism,and 1 case ofCFTR gene heterozygous mutation were detected.The most common abnormal chromosome karyotype among them is 47,XXY,with 14 cases detected.Among the 36 healthy control groups,3 cases had normal chromosomal polymorphisms.There were significant differences in the Y chromosome microdeletions and karyotype abnormalities between the male infertile group and the healthy control group.Conclusion Y chromosome microdeletions and chromosomal karyotypes abnormalities are important factors in male infertility.Conducting genetic testing before pregnancy can help patients diagnose,treat and choose appropriate reproductive assistance techniques.Provide scientific basis for eugenics.
Male infertilityY chromosome microdeletionKaryotypeEugenics
NETL
NSTL
万方数据
