Objective To investigate the relationship between HBV viral load and pregnancy complications.Methods 1595 pregnant women with hepatitis B who met the criteria were enrolled in the study.100000IU/ml was used as the cut-off value,and pregnant women with HBV-DNA quantification greater than or equal to 100000IU/ml were regarded as the high-virus-quantification group,while those with HBV-DNA quantification less than 100000IU/ml were regarded as the low-virus-quantification group,and common complications of pregnancy were analyzed in the two groups.Results The risk of fetal distress was significantly higher in the high-viral-quantification group than in the low-viral-quantification group(P＜0.05),whereas there was no significant difference between the two groups in hypertensive disorder complicating pregnancy,diabetes mellitus of pregnancy,intrahepatic cholestasis of pregnancy,anemia of pregnancy,postpartum hemorrhage,abnormal amniotic fluid,placenta praevia,premature rupture of membranes,and preterm delivery(P＞0.05).Conclusions Pregnant women with high HBV load have an increased risk of fetal distress,and attention should be paid to blocking treatment during pregnancy in this population.
Hepatitis B virusFetal distressPregnancy complications
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