Objective This study aims to analyze the current application status,results,and follow-up of Non-invasive Prenatal Testing(NIPT)in the northern county towns of Linyi,exploring the value and challenges of NIPT in prenatal screening in these areas.Methods Data from 9,892 pregnant women who underwent NIPT at the Central Hospital of Linyi between November 2022 and May 2024 were collected.Diagnostic information from the request forms,NIPT results,and follow-up data were compiled for statistical analysis and discussion.Results The analysis reveals that the population opting for NIPT as a prenatal screening tool in this region primarily includes older women,those voluntarily requesting testing,and those at marginal risk in mid-trimester serological screening.High-risk NIPT results for trisomies 21,18,and 13 were predominantly found in older individuals who missed the mid-trimester serological screening window and those requesting tests voluntarily.Chromosomal abnormalities,both sex and autosomal,were more frequently detected in older pregnant women and others with specific indications.Advanced maternal age pregnant women have a lower adherence to prenatal diagnosis.Communication between healthcare providers and these women is often challenging,and they generally have a lower acceptance of fetal sex chromosome and autosomal abnormalities.Conclusion NIPT is widely used in county towns as an effective prenatal screening method for detecting fetal chromosomal abnormalities.However,the acceptance of prenatal diagnosis following abnormal NIPT results is low among older women in these areas,leading to preventable birth defects.It is recommended that more effective birth defect awareness education be provided to older pregnant women in county towns,alongside governmental measures such as public education or financial support,to facilitate the acceptance of prenatal diagnosis and effectively prevent the occurrence of birth defects.
维普
万方数据