Research Progress on the Regulation of Protein Phosphorylation on Oocyte Maturation
The orderly progression of meiosis in mammalian oocytes is a prerequisite for successful fertilization and subsequent embryonic development,as well as the foundation for sexual reproduction.Studies have shown that many protein phosphorylation modification events are important for regulating meiotic arrest or recovery,chromosome sepa-ration,and proper spindle assembly.The article provided an overview of the role of phosphorylation modification in oocyte maturation,with a focus on the important roles played by CDK1,ERK,AURKs,PKB,Haspin,and PP1/PP2A in oocyte maturation,in order to provide reference for improving mammalian reproductive capacity and guiding female animal infertility.
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