Quantitative Study of NODDI in the Subtle Structure of Brain in Patients with Different Subtypes of Parkinson's Disease
Objective This study aimed to explore the changes in the microstructure of gray matter nuclei in different clinical subtypes of Parkinson's disease(PD)by quantitatively analyzing the neurite orientation dispersion and density imaging(NODDI).Methods A total of 29 PD patients who visited our hospital were selected and divided into tremor-dominant subtype(n=18)and rigidity-bradykinesia-dominant subtype(n=11)according to the Unified Parkinson's Disease Rating Scale(UPDRS).Routine magnetic resonance imaging(MRI)and NODDI examinations were performed.The volume fraction of intracellular volume(VIC)and orientation dispersion index(ODI)of bilateral basal ganglia nuclei were measured and averaged.Independent samples t-test was used to compare the differences in the parameters of the nuclei between the two groups.The diagnostic performance of different VIC and ODI values in the nuclei was evaluated using receiver operating characteristic(ROC)curve analysis.Multivariate logistic regression analysis was conducted to determine the independent predictors of PD.Results The VIC and ODI values of the caudate nucleus,putamen,posterior pallidum,anterior pallidum,and thalamus in the rigidity-bradykinesia-dominant PD patients were lower than those in the tremor-dominant patients(P＜0.05).In the ROC analysis,the VIC of the right pallidum showed the best diagnostic performance.Multivariate logistic regression analysis revealed that the VIC of the right pallidum was the best independent predictor.Conclusion NODDI can quantitatively reflect the microstructural changes in different clinical subtypes of PD,providing valuable reference for precise clinical treatment.
Neurite Orientation Dispersion and Density ImagingParkinson's DiseaseSubtypeMagnetic Resonance Imaging
NETL
NSTL
万方数据
维普
