Evaluation of Brain Morphologic Changes in Lung Cancer Patients after Chemotherapy Based on MRI3D-T1WI
Objective To evaluate the brain morphologic changes in lung cancer patients after chemotherapy based on MRI 3D-T1WI.Methods The 3D-T1WI Image of 34 lung cancer patients with chemotherapy,49 lung cancer patients without chemotherapy,and 40 healthy controls with matched age,sex,and years of education were retrospectively analyzed,including 14 patients had imaging both before and after chemotherapy.The brain was standardized and divided into 48 brain regions.The differences in brain region volume of the three groups(lung cancer chemotherapy,lung cancer without chemotherapy,healthy control)were statistically analyzed by univariate ANOVA test.Independent sample T test was performed between each two groups,and paired sample T test was performed for 14 patients before and after chemotherapy.Results ANOVA analysis showed that there was no significant difference in brain volume between the three groups(P＞0.05),but there were significant differences in brain regions between the two groups.For 14 patients,there were statistically significant differences in 10 brain regions(P＜0.05),including putamen(right),thalamus(total,right),globus pallidus(total,right),amygdala(total,right,left),accumbens(total,right).There was a significant negative correlation between tumor size and cerebellar gray matter(total,right)and hippocampus(total,left).Conclusion Both Lung cancer and chemotherapy caused changes in brain morphology,especially the brain volume.
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