The Value of Low-dose Dual-source CTP in Assessing Perfusion Deficits in Brain Tissue of Patients with Acute Ischemic Stroke and Its Guidance for Endovascular Recanalization Therapy
Objective To investigate the value of low-dose dual-source CT perfusion imaging(CTP)to assess brain tissue perfusion deficits in acute ischemic stroke(AIS)and to guide endovascular recanalization therapy.Methods From August 2020 to August 2022,106 patients with AIS in our hospital were randomly divided into low dose group(n=53)and conventional dose group(n=53).Low dose and conventional dose dual-source CTP were performed within 4.5 hours after the onset of the disease.Compare the CTP parameters[cerebral blood flow(CBF),cerebral blood volume(CBV),time to peak(TTP),mean transit time(MTT)],image quality,radiation dose,abnormal rate of brain tissue perfusion and area of brain tissue perfusion defect between the low-dose group and the conventional dose group,and analyze the correlation between the low-dose CTP parameters and the NIHSS score before treatment.All patients were treated with intravascular recanalization.The low-dose CTP parameters of patients with different therapeutic effects in the low-dose group were compared before treatment,and the value of low-dose CTP parameters in predicting the therapeutic effect was analyzed.Results The CTP parameters CBF,CBV,TTP,MTT,image quality score,abnormal rate of brain tissue perfusion and the area of brain tissue perfusion defect were not significantly different between the low-dose group and the conventional dose group(P＞0.05);The radiation dose of low dose group was lower than that of conventional dose group(P;The CTP parameters CBF and CBV in low dose group were negatively correlated with NIHSS score,while TTP and MTT were positively correlated with NIHSS score(P＜0.05);Before treatment,CBF and CBV of patients with poor efficacy in low-dose group were lower than those with good efficacy,while TTP and MTT were higher than those with good efficacy(P＜0.05);pre-treatment low-dose CTP parameters CBF,CBV,TTP,and MTT predicted the efficacy of endovascular recanalization therapy in AIS patients as poor The area under the curve(AUC)was 0.717,0.820,0.702,and 0.817,respectively.Conclusion Low-dose dual-source CTP can meet the clinical requirements for assessing the perfusion deficit of brain tissue in patients with AIS and can assist in clinical prediction of the efficacy of endovascular recanalization therapy,which can help guide the clinical selection of endovascular recanalization therapy.
NETL
NSTL
万方数据
维普
