IDH1突变型胶质母细胞瘤磁共振纹理特征的研究
Textural Features on Magnetic Resonance Imaging in IDH1 Mutant Glioblastoma
王汝佳 1孙静华 1侯玉微 1马梦华 1王海平 1董博文 1李秀君 1朱启航1
作者信息
- 1. 唐山市工人医院磁共振室(河北唐山 063000)
- 折叠
摘要
目的 探讨异柠檬酸脱氢酶1(isocitrate dehydrogenase 1,IDH1)突变型胶质母细胞瘤(Glioblastoma,GBM)的磁共振纹理特征.方法 共纳入118例GBM患者.通过横断位T1WI增强图像,采用3D slicer软件选取的31种磁共振纹理特征进行分析.通过SPSS 26.0软件,研究IDH1突变型GBM与其磁共振纹理特征的联系,采用了 x2检验、独立样本T检验以及Mann-Whitney U检验分析方法;生存分析采用的Kaplan-Meier单因素方法.结果 IDH1突变型GBM与IDH1野生型GBM相比,磁共振纹理特征共有18种有明显差异,包括运行百分比、表面:体积比、能量、熵、一致性、自相关、集群突出、聚类趋势、差值熵、能量:灰度共生矩阵、熵:灰度共生矩阵、同质性1、平均总和、熵和、方差和、方差、GLN、群集阴影.结论 3D slicer中有18种磁共振纹理特征可以IDH1突变型GBM关系密切.
Abstract
Objective To investigate the texture on Magnetic Resonance Imaging and prognosis in isocitratedehydrogenase-1(IDH1)mutant glioblastoma.MethodsA total of 118 GBM were included by the pathological diagnosis.31 texture of MRI were extracted from 3D slicer.Using SPSS 22.0 analysis software,the x 2 test,Student's t-test and Mann-Whitney U-test were conducted to analysis the relationship between the status of IDH1and MRI textural features in GBM.ResultsThe IDH1 mutant GBM was compared with IDH1 wild-type GBM,there were 18 of Magnetic resonance textural features which were significantly different,including Run Percentage(RP)、Surface:Volume Ratio、Energy、Entropy、Uniformity、Auto-correlation、Cluster Prominence、Cluster Tendency、Difference Entropy、Energy:Gray Level Co Occurrence Matrix(GLCM)、Entropy:Gray Level Co Occurrence Matrix(GLCM)、Homogeneity 1、Sum Average、Sum Entropy、Sum Variance、Variance:Gray Level Co Occurrence Matrix(GLCM)、GLN、Cluster Shade.Conclusion IDH1 mutant GBM were compared with IDH1 wild-type GBM,there were significantly different about 18 MRI textural features.
关键词
胶质母细胞瘤/IDH1状态/磁共振纹理特征/预后Key words
Glioblastoma/The Status of IDH1/Textural Feature on Magnetic Resonance Imaging/Prognosis引用本文复制引用
基金项目
2021年度河北省医学科学研究课题计划(20210447)
出版年
2024
NETL
NSTL
维普
万方数据