首页|IDH1突变型胶质母细胞瘤磁共振纹理特征的研究

IDH1突变型胶质母细胞瘤磁共振纹理特征的研究

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目的 探讨异柠檬酸脱氢酶1(isocitrate dehydrogenase 1,IDH1)突变型胶质母细胞瘤(Glioblastoma,GBM)的磁共振纹理特征.方法 共纳入118例GBM患者.通过横断位T1WI增强图像,采用3D slicer软件选取的31种磁共振纹理特征进行分析.通过SPSS 26.0软件,研究IDH1突变型GBM与其磁共振纹理特征的联系,采用了 x2检验、独立样本T检验以及Mann-Whitney U检验分析方法;生存分析采用的Kaplan-Meier单因素方法.结果 IDH1突变型GBM与IDH1野生型GBM相比,磁共振纹理特征共有18种有明显差异,包括运行百分比、表面:体积比、能量、熵、一致性、自相关、集群突出、聚类趋势、差值熵、能量:灰度共生矩阵、熵:灰度共生矩阵、同质性1、平均总和、熵和、方差和、方差、GLN、群集阴影.结论 3D slicer中有18种磁共振纹理特征可以IDH1突变型GBM关系密切.
Textural Features on Magnetic Resonance Imaging in IDH1 Mutant Glioblastoma
Objective To investigate the texture on Magnetic Resonance Imaging and prognosis in isocitratedehydrogenase-1(IDH1)mutant glioblastoma.MethodsA total of 118 GBM were included by the pathological diagnosis.31 texture of MRI were extracted from 3D slicer.Using SPSS 22.0 analysis software,the x 2 test,Student's t-test and Mann-Whitney U-test were conducted to analysis the relationship between the status of IDH1and MRI textural features in GBM.ResultsThe IDH1 mutant GBM was compared with IDH1 wild-type GBM,there were 18 of Magnetic resonance textural features which were significantly different,including Run Percentage(RP)、Surface:Volume Ratio、Energy、Entropy、Uniformity、Auto-correlation、Cluster Prominence、Cluster Tendency、Difference Entropy、Energy:Gray Level Co Occurrence Matrix(GLCM)、Entropy:Gray Level Co Occurrence Matrix(GLCM)、Homogeneity 1、Sum Average、Sum Entropy、Sum Variance、Variance:Gray Level Co Occurrence Matrix(GLCM)、GLN、Cluster Shade.Conclusion IDH1 mutant GBM were compared with IDH1 wild-type GBM,there were significantly different about 18 MRI textural features.

GlioblastomaThe Status of IDH1Textural Feature on Magnetic Resonance ImagingPrognosis

王汝佳、孙静华、侯玉微、马梦华、王海平、董博文、李秀君、朱启航

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唐山市工人医院磁共振室(河北唐山 063000)

胶质母细胞瘤 IDH1状态 磁共振纹理特征 预后

2021年度河北省医学科学研究课题计划

20210447

2024

中国CT和MRI杂志
北京大学深圳临床医学院 北京大学第一医院

中国CT和MRI杂志

CSTPCD
影响因子:1.578
ISSN:1672-5131
年,卷(期):2024.22(1)
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