Relationship between 18F-FDG PET/CT Metabolic Parameters and Clinicopathological Features in Patients with Nasopharyngeal Carcinoma and Their Predictive Value for Local Recurrence
ObjectiveTo investigate the relationship between 18F-deoxyglucose(FDG)positron emission computed tomography(PET/CT)metabolic parameters and clinicopathological characteristics of patients with nasopharyngeal carcinoma and its predictive value for local recurrence,and to provide a reliable basis for clinical diagnosis and treatment.Methods Two hundred patients with nasopharyngeal carcinoma who underwent radiotherapy Sun Yat-sen University Cancer Center from January 2020 to January 2022 were selected as study subjects and divided into recurrence group(n=85)and non-recurrence group(n=115)according to their recurrence within 6 months after treatment.Clinicopathological characteristics and 18F-FDG PET/CT metabolic parameters were compared between the two groups.The relationship between different parameters and clinicopathological features and their predictive value for local recurrence were analyzed.To analyze the risk of local recurrence in those with different expression of each parameter.Results The proportion of clinical stage Ⅰ to Ⅱ in the recurrence group was lower than that in the non-recurrence group,and the proportion of lymph node metastasis and 18F-FDG PET/CT metabolic parameters maximum standardized uptake value(SUVmax),mean standardized uptake value(SUVmean),peak standardized uptake value(SUVpeak),total glycolysis of the lesion(TLG),and tumor metabolic volume(MTV)were higher than those in the non-recurrence group(P＜0.05).SUVmax,MTV,and TLG were positively correlated with clinical stage and lymph node metastasis(P＜0.05);the AUC of local recurrence predicted by the combination of SUVmax,SUVpeak,SUVmean,MTV,and TLG was higher than that of single prediction(P＜0.05);the risk of local recurrence was 2.406 times,3.189 times,and 4.170 times higher for high levels of each parameter than for low levels,respectively.2.374 times,3.102 times,and 4.170 times for high levels of each parameter,respectively.Condusion The 18F-FDG PET/CT metabolic parameters SUVmax,MTV,and TLG correlate with the clinicopathological characteristics of patients with nasopharyngeal carcinoma,and their combination with SUVpeak and SUVmean has some predictive value in predicting local recurrence.
NETL
NSTL
万方数据
维普
